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Products
Pharmacology
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- Technical support
- Resources
Batimastat
Cat. No. MM-010
Structure:
(2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamine)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
Other Names:
BB-94
Activity:
Matrix metalloproteinase inhibitor
Batimastat is a potent, broad spectrum MMP inhibitor with IC50s values of 3, 4, 4, 6 and 20 nM for MMPs -1, -2, -9, -7 and -3 respectively. Metalloproteinases play a necessary role in invasion and angiogenesis and batimastat exhibits antiproliferative, anti-invasive and antimetastatic activity in human colon, ovarian and prostate xenografts. Batimastat attenuates neuroinflammation following focal cerebral ischemia in mice.
Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53(9) 2087 PMID: 8347186
Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55(9) 1856 PMID: 7728753
Lein et al (2000) Synthetic inhibitor of matrix metalloproteinases (batimastat) reduces prostate cancer growth in an orthotopic rat model. Prostate 43(2) 77 PMID: 10754522
Park et al (2011) Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice. Korean J Physiol Pharmacol. 15(2) 115 PMID: 21660152
Mustafa et al (2022) Insights Into the Role of Matrix Metalloproteinases in Cancer and its Various Therapeutic Aspects: A Review. Front Mol Biosci. 9 896099 PMID: 36250005
Related areas
All small molecules >
All matrix metalloproteinase modulators >
All cancer research categories >
Technical Data
| Structure | (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamine)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide |
| CAS Number | 130370-60-4 |
| Molecular Weight | 477.64 |
| Formula | C23H31N3O4S2 |
Solubility and Storage
| Solubility | Soluble in DMSO to 45 mg/ml |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by HPLC, NMR conforms |
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Recent citations
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