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Products
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- Resources
Phosphoramidon disodium
Cat. No. PI-130
Structure:
N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan
Activity:
Metalloendopeptidase inhibitor
Phosphoramidon is a metalloendopeptidase inhibitor originally derived from cultures of Streptomyces tanashiensis. Phosphoramidon is a potent inhibitor of thermolysin and other metallo-endopeptidases and also strongly inhibits mammalian enkephalinase but does not inhibit trypsin, papain, chymotrypsin or pepsin. Phosphoramidon has been used as a neprilysin (NEP) inhibitor to study amyloid beta (Aβ) uptake and degradation.
Bao et al (2016) Deacetylation of TFEB promotes fibrillar Aβ degradation by upregulating lysosomal biogenesis in microglia. Protein Cell 7(6) 417 PMID: 27209302
Goblirsch et al (2018) Phosphoramidon inhibits the integral membrane protein zinc metalloprotease ZMPSTE24. Acta. Crystallogr. D Struct. Biol. 74(Pt 8) 739 PMID: 30082509
Li et al (2018) SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes. Neural Regen. Res. 13(11) 2005 PMID: 30233076
Related areas
All small molecules >
All matrix metalloprotease modulators >
Technical Data
| Structure | N-(α-Rhamnopyranosyloxyhydroxyphosphinyl)-L-leucyl-L-tryptophan |
| CAS Number | 119942-99-3 |
| Molecular Weight | 587.47 |
| Formula | C23H32N3O10P•2Na |
| Sequence | LW |
| Modifications | N-(α-Rhamnopyranosyloxyhydroxyphosphinyl at N terminal |
Solubility and Storage
| Solubility | 50 mg per ml in water |
| Appearance | Off white powder |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | ≥97% (HPLC) |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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