Neuromedin U receptors

Neuromedin U receptors exist as two subtypes, neuromedin U receptor 1 (NMU1) and neuromedin U receptor 2 (NMU1).   Neuromedin U receptors have distinct physiological functions in peripheral tissues and in the central nervous system, according to their tissue distributions.   NMU1 is expressed predominantly in the peripheral nervous system, with highest levels in the gastrointestinal tract, whereas NMU2 is mainly found in the CNS, with greatest expression in the hypothalamus, medulla, and spinal cord.   NMU1 and NMU2 receptors are stimulated by two endogenous neuropeptides, neuromedin U and neuromedin S, which have similar binding affinities.  Neuromedin U receptors are involved in a variety of physiological functions, including the regulation of blood pressure, food uptake, nociception, pain, bone formation, and immunological responses.

Further reading

Raddatz et al (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem. 275(42) 32452 PMID: 10899166

Brighton et al (2004) Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev. 56(2) 231 PMID: 15169928

You et al (2022) Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun. 13(1) 2045 PMID: 35440625

Neuromedin U receptors - Guide to Pharmacology