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PR 619
Cat. No. PI-150
Structure:
2,6-Diamino-3,5-dithiocyanopyridine
Activity:
Broad spectrum deubiquitinylating enzyme (DUB) inhibitor
PR 619 is a broad spectrum, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with an EC50 of 1-20 μM in a cell-free assay and only limited activity against other proteases. PR 619 induces accumulation of polyubiquitinated proteins, but has no direct inhibitory effect on the proteasome. PR 619 is cytotoxic in HEK293T and colorectal cancer cells and stabilizes microtubule networks in oligodendroglial cells.
Altun et al (2011) Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Chem.Biol. 18 1401 PMID: 22118674
Seiberlich et al (2012) The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: implications for neurodegenerative diseases. Biochim.Biophys.Acta 1823 2057 PMID: 22565157
Related areas
All small molecules >
All deubiquitinating enzyme modulators >
All cancer research areas >
Technical Data
| Structure | 2,6-Diamino-3,5-dithiocyanopyridine |
| CAS Number | 2645-32-1 |
| Molecular Weight | 223.28 |
| Formula | C7H5N5S2 |
| Sequence | 2,6-Diamino-3,5-dithiocyanopyridine |
Solubility and Storage
| Solubility | Soluble to 10 mM in DMSO |
| Appearance | Light brown solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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