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Products
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- Technical support
- Resources
NSC 632839
Cat. No. PI-080
Structure:
3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride
Other Names:
F6
Activity:
Ubiquitin isopeptidase inhibitor
NSC 632839, also known as F6, targets the ubiquitin-proteasome system by inhibiting ubiquitin isopeptidases. NSC 632839 is able to activate an apoptosome-independent apoptotic pathway which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the inhibitor of apoptosis antagonist Smac, and also the involvement of the death receptor pathway
Aleo et al (2006) Identification of New Compounds That Trigger Apoptosome-Independent Caspase Activation and Apoptosis. Cancer Res. 66(18) 9235 PMID: 16982768
Related areas
All small molecules >
All deubiquitinating enzyme modulators >
All regulated cell death categories >
Technical Data
| Structure | 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride |
| CAS Number | 157654-67-6 |
| Molecular Weight | 339.86 |
| Formula | C21H21NO.HCl |
| Sequence | 3,5-Bis[(4-methylphenyl)methylene]-4-piperidone hydrochloride |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | White solid |
| Storage | Stotre, dry, frozen and in the dark |
Batch Specific Data
| Purity | >98% by tlc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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