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BMP2pp
Cat. No. RK-010
Structure:
H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH
Other Names:
Bone morphogenetic protein-2 functional polypeptide, 73-92 peptide
Activity:
BMP-2 mimetic
BMP2pp is a peptide corresponding to residues 73-92 of the knuckle epitope of bone morphogenetic protein-2 (BMP-2) which inhibits the binding of human recombinant BMP-2 to both BMP receptors type IA and type II. BHP2pp has the same receptor binding capacity and osteogenic properties as the full BMP-2 protein and can promote the formation and regeneration of bone and cartilage, participate in organogenesis, cell differentiation, cell proliferation and apoptosis, but is more stable. In models of artificial joint replacement wear, BMP2pp can ameliorate the Titanium (Ti) mediated impairment in osteogenic potential of human placenta derived mesenchymal stem cells (hPMSCs), suppress the M1 polarization of macrophages through inhibition of the activation of the NF-κB signaling pathway, and ameliorate Ti-induced bone osteolysis. The sequence with a GGC linker at the C teminal, BMP-2 derived peptide, is also available
Saito et al (2003) Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim Biophys Acta 1651(1-2) 60 PMID: 14499589
Madl (2014) Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells. Biomacromolecules 15(2) 445 PMID: 24400664
Wang et al (2023) BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization. NPJ Regen Med. 8(1) 6 PMID: 36759627
Related areas
All peptides >
All receptor serine/threonine kinase receptors >
All immunology categories >
All stem cell research categories >
Technical Data
| Structure | H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH |
| Molecular Weight | 2117.20 |
| Formula | C97H164N22O30 |
| Sequence | KIPKASSVPTELSAISTLYL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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