Natriuretic peptide receptors

Natriuretic peptide receptors are single transmembrane catalytic receptors with intracellular guanylyl cyclase activity.  There are three isoforms of Natriuretic peptide receptors; NPR1, NPR2 and NPR3, which have conserved catalytic and regulatory domains and divergent ligand binding domains.  Natriuretic peptide receptors bind α-atrial natriuretic peptide, brain natriuretic peptide and type C-natriuretic peptide with varying affinity and are found in the brain, vasculature and kidney.  The main physiological role of natriuretic peptide receptors is the homeostasis of body fluid volume.

Further reading

Hirose et al (2001) Comparative molecular biology of natriuretic peptide receptors. Can. J. Physiol. Pharmacol. 79 (8) 665 PMID 11558675

Potter et al (2009) Natriuretic peptides: their structures, receptors, physiologic functions and therapeutic applications. Handbook Exp. Pharmacol. 191 341 PMID: 19089336 

Nagai‐Okatani et al (2017) Three molecular forms of atrial natriuretic peptides: quantitative analysis and biological characterization. J. Pept. Sci. 23 486 PMID: 28120499