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Products
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A 83-01
Cat. No. RK-020
Structure:
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Activity:
TGF-βRI, ALK4 and ALK7 inhibitor
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM respectively, and only weak inhibition of ALK-1, -2, -3, -6 and MAPK. A 83-01 inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. A 83-01 helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (hPSCs) and also promotes neural differentiation of hPSCs as part of a chemical cocktail.
Tojo et al (2005) The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 96(11) 791 PMID: 16271073
Li et al (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4(1) 16 PMID: 19097958
Chen et al (2015) Pharmacological inhibition of TGFβ receptor improves Nkx2.5 cardiomyoblast-mediated regeneration. Cardiovasc Res. 105(1) 44 PMID: 25362681
Related areas
All small molecules >
All receptor serine/threonine kinase receptor modulators >
All stem cell research categories >
Technical Data
| Structure | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| CAS Number | 909910-43-6 |
| Molecular Weight | 421.53 |
| Formula | C25H19N5S |
Solubility and Storage
| Solubility | Soluble in DMSO to 20 mg/ml |
| Appearance | Light yellow solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by TLC, NMR conforms |
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Recent citations
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