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Products
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- Technical support
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CP-EPS8-NLS
Cat. No. NR-190
Structure:
Ac-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-Ser-Lys-Arg-Lys-Lys-Asn-Lys-Lys-Gly-Lys-Arg-Lys-NH2
Activity:
Downregulates EPS8 expression
CP-EPS8-NLS is a peptide derived from the nuclear localization signal (NLS) of epidermal growth factor receptor (EGFR) pathway substrate no.8 (EPS8) (amino acids 298-310), conjugated at the N-terminal to Tat (48 - 60) to facilitate cell penetration. EPS8 is an important signaling molecule that integrates multiple pathways, and elevated EPS8 expression levels are critical in tumourigenesis, proliferation, invasion and metastasis. NLS residues of tumour associated proteins are crucial for cell cycle progression and the core NLS (298–310) domain acts to guide EPS8 to the nucleus. CP-EPS8-NLS interferes with the nuclear translocation of EPS8, downregulating EPS8 expression and blocking its downstream pathways. In a nude mouse xenograft assay, CP-EPS8-NLS potently lowers acute myeloid leukemia (AML) tumour sizes, an effect synergistic with the chemotherapeutic agents daunorubicin, cytarabine and adriamycin.
Chen et al (2018) A synthetic cell-penetrating peptide derived from nuclear localization signal of EPS8 exerts anticancer activity against acute myeloid leukemia. J Exp Clin Cancer Res. 37(1) 12 PMID: 29357910
Related areas
All cell penetrating peptides >
All nuclear receptor modulators >
All cancer research categories >
Technical Data
| Structure | Ac-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-Ser-Lys-Arg-Lys-Lys-Asn-Lys-Lys-Gly-Lys-Arg-Lys-NH2 |
| Molecular Weight | 3226.04 |
| Formula | C135H256N62O30 |
| Sequence | Ac-GRKKRRQRRRPPQSKRKKNKKGKRK-NH2 |
| Modifications | N terminal acetyl, C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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