The product has been added to the cart.
By using our website, you agree to our use of cookies. find out more.
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
-
Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Tat-NTS peptide
Cat. No. PP-260
Structure:
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
Other Names:
Tat-NTS
Activity:
Blocks the interaction of ANXA1 with importin β
Tat-NTS peptide is a cell-penetrating peptide consisting of Tat fused to amino acid residues R228 to F237 of the repeat III domain of ANXA1, which functions as a unique
nuclear translocation signal (NTS). Tat-NTS peptide specifically blocks the interaction of ANXA1 with importin β and consequently the nuclear translocation of ANXA1. Tat-NTS peptide inhibits the transcriptional activity of p53, decreases Bid expression, suppresses activation of the caspase-3 apoptosis pathway and improves survival of neurons subjected to oxygen-glucose deprivation in vitro. In a focal brain ischemia animal model, Tat-NTS peptide reduces neuronal apoptosis in the ischemic zone and effects a dramatic reduction of infarct volume and a parallel improvement in neurological function after reperfusion.
Li et al (2019) A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. 26(2) 260 PMID: 29769639
Related areas
All cell penetrating peptides >
All protein-protein modulators >
All nuclear receptor modulators >
All neuroscience categories >
Technical Data
| Structure | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2 |
| Molecular Weight | 2855.40 |
| Formula | C125H212N54O24 |
| Sequence | YGRKKRRQRRRRSFPHLRRVF-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
Contact Information
To place an order, or for customer services, order processing or technical support please contact us on:
UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
[email protected]
USA and Canada
Tel: 610-994-1134
Toll Free: 855-FOCUS21 (855-362-8721)
Fax: 610-465-9100
France
CliniSciences
Tel : +33 9 77 40 09 09
Fax : +33 9 77 40 10 11
Orders and customer support : [email protected]
Germany, Switzerland, Austria
BIOZOL Diagnostics
Tel: +49 (089) 3799 666-6
Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: [email protected]
Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: [email protected]
Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80
Fax: +34 94 404 80 81
Orders: [email protected]
BIOHUB INTERNATIONAL
上海起发实验试剂有限公司
Tel: +86-15921799099
Tel: +86-021-50724187
Fax: +86-021-50724961
Orders: [email protected]
India
Biotechno Labs
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: [email protected]
Japan
Namiki Shoji Co.
Tel：+81-050-5527-9850
Fax：+81-3-3352-2196
email: [email protected]
Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
Learn more
© 2022 Isca Biochemicals. All rights reserved.
Designed and developed by tocostudio