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Tat-NTS peptide

Cat. No. PP-260

Structure:

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2

Other Names:

Tat-NTS

Activity:

Blocks the interaction of ANXA1 with importin β

Price Qty
1 mg    $ 215.00

Tat-NTS peptide is a cell-penetrating peptide consisting of Tat fused to amino acid residues R228 to F237 of the repeat III domain of ANXA1, which functions as a unique nuclear translocation signal (NTS).  Tat-NTS peptide specifically blocks the interaction of ANXA1 with importin β and consequently the nuclear translocation of ANXA1.  Tat-NTS peptide inhibits the transcriptional activity of p53, decreases Bid expression, suppresses activation of the caspase-3 apoptosis pathway and improves survival of neurons subjected to oxygen-glucose deprivation in vitro.  In a focal brain ischemia animal model, Tat-NTS peptide reduces neuronal apoptosis in the ischemic zone and effects a dramatic reduction of infarct volume and a parallel improvement in neurological function after reperfusion.

Li et al (2019) A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell Death Differ. 26(2) 260 PMID: 29769639

Related areas

All cell penetrating peptides >
All protein-protein modulators >
All nuclear receptor modulators >
All neuroscience categories >


Technical Data

Structure H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Arg-Ser-Phe-Pro-His-Leu-Arg-Arg-Val-Phe-NH2
Molecular Weight 2855.40
Formula C125H212N54O24
Sequence YGRKKRRQRRRRSFPHLRRVF-NH2
Modifications C terminal amide

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
[email protected]

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Tel: 610-994-1134

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France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
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Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
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Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
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Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
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China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: [email protected]

India
Biotechno Labs
Tel: +91-8860924629
07291852429
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Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email: [email protected]


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