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SRC-1 (676–700), biotinylated
Cat. No. PP-020
Structure:
Biotin-Cys-Pro-Ser-Ser-His-Ser-Ser-Leu-Thr-Glu-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-OH
Other Names:
Biotin-SRC-1, Biotinylated steroid receptor coactivator-1 peptide
Activity:
Biotinylated peptide derived from the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1
SRC-1 (676–700), biotinylated, also known as biotin-SRC-1, or biotinylated steroid receptor coactivator-1 peptide, is a biotinylated 25-mer peptide derived from amino acids 676-700 of the transcriptional coregulatory protein human nuclear receptor coactivator SRC-1. SRC-1 (676–700), biotinylated has been used in AlphaScreen, time-resolved fluorescence (TRF), and time-resolved fluorescence energy transfer (TR-FRET) assays for various nuclear receptors including assays for the ROR family proteins RORα, RORβ and RORγt, a farnesoid X receptor (FXR) assay, and human PPARα, PPARγ, and PPARδ assays. SRC-1 (676–700), biotinylated contains a covalently bonded N-terminal biotin tag that can be used for detection and purification.
Wu et al (2003) Comparison of Assay Technologies for a Nuclear Receptor Assay Screen Reveals Differences in the Sets of Identified Functional Antagonists. J. Biomol. Screen. 8(4) 381 PMID: 14567790
Chen et al (2010) Cevoglitazar, a Novel Peroxisome Proliferator-Activated Receptor-α/γ Dual Agonist, Potently Reduces Food Intake and Body Weight in Obese Mice and Cynomolgus Monkeys, Endocrinology 151(7) 3115 PMID: 20484464
Yang et al (2019) Discovery of betulinaldehyde as a natural RORγt agonist. Fitoterapia 137 104200 PMID: 31195082
Related areas
All biotin labelled peptides >
All nuclear receptor modulators >
Technical Data
| Structure | Biotin-Cys-Pro-Ser-Ser-His-Ser-Ser-Leu-Thr-Glu-Arg-His-Lys-Ile-Leu-His-Arg-Leu-Leu-Gln-Glu-Gly-Ser-Pro-Ser-OH |
| Molecular Weight | 3127.22 |
| Formula | C128H209N41O40S2 |
| Sequence | Biotin-CPSSHSSLTERHKILHRLLQEGSPS |
| Modifications | N terminal is biotinylated |
Solubility and Storage
| Solubility | Soluble in water and physiological buffers |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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