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Products
Pharmacology
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aCx26-pep
Cat. No. NR-200
Structure:
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Arg-Tyr-Cys-Ser-Gly-Lys-Ser-Lys-Lys-Pro-Val-NH2
Other Names:
Cx26 peptide
Activity:
Cx26 interaction region mimetic
aCx26-pep is a peptide consisting of the gap junction protein connexin 26 (Cx26) cytosolic tail sequence, coupled to antennapedia. Triple negative breast cancer (TNBC) is one of the most lethal and treatment resistant breast cancer subtypes and it contains a unique protein complex composed of Cx26, the pluripotency transcription factor NANOG, and focal adhesion kinase (FAK), with the Cx26 cytosolic tail being essential for interaction with NANOG and FAK. In vitro, in breast cancer cells, aCx26-pep treatment decreases FAK and NANOG levels and alters NANOG function, and also decreases tumoursphere frequency. In vivo, in an NSG mouse model, aCx26-pep reduces TNBC tumour growth and proliferation and induces cell death.
Mulkearns-Hubert et al (2023) Targeting NANOG and FAK via Cx26-derived cell-penetrating peptides in triple-negative breast cancer. Mol Cancer Sep 13 Epub ahead of print. PMID: 37703580
Related areas
All cell penetrating peptides >
All protein-protein interaction modulators >
All nuclear receptor modulators >
All cancer research categories >
Technical Data
| Structure | H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Arg-Tyr-Cys-Ser-Gly-Lys-Ser-Lys-Lys-Pro-Val-NH2 |
| Molecular Weight | 3477.97 |
| Formula | C158H260N52O33S2 |
| Sequence | RQIKIWFQNRRMKWKKRYCSGKSKKPV-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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