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TAT-ANK

Cat. No. PP-270

Structure:

H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH

Other Names:

ANK peptide

Activity:

Dll4-Notch1 inhibitor
Price Qty
1 mg    $ 189.00

TAT-ANK is a peptide derived from amino acid residues 179–191 of the G-protein coupled receptor kinase interacting protein-1 (GIT1) ankyrin domain, which are are crucial for GIT1 binding to the Notch transcription repressor RBP-J.  In vitro, application of TAT-ANK significantly inhibits Delta-like 4 (Dll4) expression and Notch 1 activation in human umbilical vein endothelial cells (HUVECs) by competing with activated Notch1 binding to RBP-J, and in mouse models, TAT-ANK reduces tumour size through impairing tumour angiogenesis.

Zhu et al (2022) A novel peptide inhibitor of Dll4-Notch1 signalling and its pro-angiogenic functions. Br J Pharmacol. 1-16 PMID: 34796471


Related areas

All cell penetrating peptides >
All protein-protein interaction modulators >
All cancer research areas >


Technical Data

Structure H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gln-Thr-Leu-Gln-Ala-Glu-Leu-Leu-Val-Val-Tyr-Gly-Ala-OH
Molecular Weight 2946.45
Formula C128H221N47O33
Sequence YGRKKRRQRRRQTLQAELLVVYGA
Modifications None

Solubility and Storage

Solubility Soluble in 50% DMSO and 50% sterile H2O
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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