Transient receptor potential (TRP) channels

Transient receptor potential (TRP) channels are a superfamily of cation channels that are currently subdivided into 9 proposed families split into two groups, each family containing a number of subfamilies. TRP channels are expressed ubiquitously and are activated by a wide range of stimuli. TRP subunits assemble into homo- or heterotetramers and are often functionally associated with G-protein-coupled receptors, receptor tyrosine kinases and phospholipase C and are regulated by the multipotent phosphatidylinositol pathway. As TRPs are intimately linked with intracellular Ca2+ signaling, they are implicated in the control of cell cycle progression, cell migration and apoptosis.

Cell penetrating peptides

Cat No.	Product Name	Activity
PP-160	736-745-TAT	Inhibits the interaction of TRPV1 and AKAP79
PP-180	Myr-tat-CBD3	Blocks the CaV2.2–CRMP2 interaction
PP-190	T100-Mut	Enhances the association of TRPA1 and TRPV1
PP-130	TAT-AKAP79 (326-336)	The key region of AKAP79 for interaction with TRPV1
TP-010	tatM2NX	Cell permeable TRPM2 antagonist

Peptides

Cat No.	Product Name	Activity
PN-210	Bradykinin	Endogenous bradykinin receptor agonist
TP-020	SOR-C13	TRPV6 antagonist
TP-030	TIP	TRPV1 inhibitor
PN-120	WaTx	Stabilizes the transient receptor potential cation channel 1 (TRPA1) in an active state

Further reading

Venkatachalam and Montell (2007) TRP channels. Annu. Rev. Biochem. 76 387 PMID: 17579562

Nilius (2007) TRP channels in disease, Biochimica Biophysica Acta (BBA) - Molecular Basis of Disease 1772 (8) 805 PMID: 17368864

Samanta et al (2018). Transient Receptor Potential (TRP) Channels. Sub-cellular biochemistry 87 141 PMID: 29464560

Zhang et al (2023) TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduct Target Ther. 8(1) 261 PMID: 37402746

Dong et al (2025) TRPV2 mediates stress resilience in mouse cardiomyocytes. Commun Biol 8 715 https://doi.org/10.1038/s42003-025-08167-9

Related Targets

Calcium channels Gap junction channels Ligand-gated ion channels Potassium channels

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Pharmacology

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Pharmacology

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Pharmacology

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Transient receptor potential (TRP) channels

Cell penetrating peptides

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