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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
Calcium channels
Calcium channels are ion channels which show selective permeability to calcium ions. There are two main types of calcium channels; voltage-gated calcium channels, which open in response to changes in membrane potential, and ligand-gated calcium channels, which are activated by ligand binding. Multiple diseases are caused by disruption of normal calcium channel function. Inherited calcium channelopathies include nervous system disorders, such as X-linked night blindness and migraine, muscloskeletal disorders, and cardiovascular disorders.
Cell penetrating peptides
| Cat No. | Product Name | Activity |
|---|---|---|
| PP-180 | Myr-tat-CBD3 | Blocks the CaV2.2–CRMP2 interaction |
| PP-140 | TAT-CBD3 | CRMP2 - CaV2.2 interaction inhibitor |
| PP-150 | TAT-CBD3A6K | Optimised variation of CBD3 |
Further reading
Striggow and Ehrlich (1996) Ligand-gated calcium channels inside and out. Curr. Opin. Cell Biol. 8(4) 490 PMID: 8791458
Zamponi et al (2010) Role of voltage-gated calcium channels in epilepsy. Pflugers Arch. 460(2) 395 PMID: 20091047
Nanou and Catterall (2018) Calcium Channels, Synaptic Plasticity, and Neuropsychiatric Disease. Neuron 98 (3) 466 PMID: 29723500
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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