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Products
Pharmacology
Type
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- Technical support
- Resources
TIP
Cat. No. TP-030
Structure:
H-Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr-OH
Other Names:
TRPV1 inhibitory peptide
Activity:
TRPV1 inhibitor
TIP, or TRPV1 inhibitory peptide (TIP) is a TRPV1 inhibitor corresponding to amino acids 701-709 of the TRPV1 receptor, with Thr705 included as a key component as phosphorylation of this residue causes conformational change and opening of the TRPV1 channel. In cell lines, TIP effectively inhibits capsaicin induced calcium influx and TRPV1 activation and treatment of the immortalised human keratinocyte cell line HaCaT with TIP prevents UV induced increases of MMP-1 and pro-inflammatory cytokines. In mouse skin, TIP inhibits UV induced skin thickening and prevents UV induced expression of MMP-13 and MMP-9. TIP can also attenuate UV induced erythema and the expression of MMP-1, MMP-2, IL-6, and IL-8 in human skin in vivo.
Kang et al (2017) A synthetic peptide blocking TRPV1 activation inhibits UV-induced skin responses. J Dermatol Sci. 88(1) 126 PMID: 28551094
Related areas
All peptides >
All transient receptor potential (TRP) channel modulators >
All immunology research categories >
Technical Data
| Structure | H-Gln-Arg-Ala-Ile-Thr-Ile-Leu-Asp-Thr-OH |
| Molecular Weight | 1029.58 |
| Formula | C44H79N13O15 |
| Sequence | QRAITILDT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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