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Ion channel modulators
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Transient receptor potential (TRP) channels
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736-745-TAT
736-745-TAT
Cat. No. PP-160
Structure:
H-Lys-Asp-Asp-Tyr-Arg-Trp-Cys-Phe-Arg-Val-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH
Other Names:
TAT-TRPV1(736-745)
Activity:
Inhibits the interaction of TRPV1 and AKAP79
736-745-TAT, also known as TAT-TRPV1(736-745), is a cell permeable TRPV1 fragment that can inhibit the interaction of TRPV1 and AKAP79. 736-745-TAT consists of amino acids 736-749 from the TRPV1 C-terminal domain, combined with amino acids 47–57 of TAT to promote uptake across neuronal cell membranes. 736-745-TAT inhibits both the first and the second phase of pain behaviour in the formalin test, implying an effect on both acute and inflammatory pain.
Fischer et al (2013) Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 33(17) 7407 PMID: 23616546
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Technical Data
| Structure | H-Lys-Asp-Asp-Tyr-Arg-Trp-Cys-Phe-Arg-Val-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH |
| Molecular Weight | 2929.41 |
| Formula | C127H206N50O29S1 |
| Sequence | KDDYRWCFRVYGRKKRRQRRR |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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