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- Technical support
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PGLa
Cat. No. AM-400
Structure:
H-Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2
Other Names:
PGLA
Activity:
Antimicrobial peptide
PGLa is an antibiotic peptide member of the magainin family, originally identified in the skin of the African frog Xenopus laevis and its secretions. PGLa has antibacterial, antifungal, and antiviral properties, acting on gram-negative and gram-positive bacteria via disruption of the cellular lipid bilayer and inducing transmembrane pore formation. In common with other magainins, PGLa does not exhibit hemolytic activity. When used in combination with magainin 2, PGLa has a synergistic effect, which it also demonstrates when used in combination with other antibiotics. PGLa can also restore antibiotic activity in resistant bacteria, and inhibit evolution of antibiotic resistance. Used in combination, a sub-inhibitory dose of PGLa causes a 30 fold increase in susceptibility in antibiotic resistant bacteria, and the same sub-inhibitory dose efficiently slows down the development of antibiotic resistance.
Gibson et al (1986) Novel peptide fragments originating from PGLa and the caerulein and xenopsin precursors from Xenopus laevis. J Biol Chem. 261(12) 5341 PMID: 3957928
Blazyk et al (2001) A novel linear amphipathic beta-sheet cationic antimicrobial peptide with enhanced selectivity for bacterial lipids. J Biol Chem. 276(30) 27899 PMID: 11352918
Lázár et al (2018) Antibiotic-resistant bacteria show widespread collateral sensitivity to antimicrobial peptides. Nat Microbiol. 3(6) 718 PMID: 29795541
Ma et al (2020) Individual Roles of Peptides PGLa and Magainin 2 in Synergistic Membrane Poration. Langmuir 36(26) 7190 PMID: 32529830
Related areas
All antimicrobial peptides >
All antibacterial agents >
All antifungal agents >
All antiviral agents
Technical Data
| Structure | H-Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2 |
| CAS Number | 102068-15-5 |
| Molecular Weight | 1968.46 |
| Formula | C88H162N26O22S |
| Sequence | GMASKAGAIAGKIAKVALKAL-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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