Chemerin receptors

Chemerin is a chemoattractant protein and adipokine, and the endogenous ligand for the chemerin family receptors chemerin receptor 1 (CMKLR1, chemerin1) and chemerin receptor 2 (chemerin2).  Chemerin and its receptors are widely expressed in humans, rats and mice, and both chemerin receptors share  approximately 80% identity in these species.  Chemerin is initially secreted by the liver and white adipose tissue as prochemerin, a 163-amino acid precursor protein which is readily converted into active chemerin by various proteases. 

Depending on the site of cleavage and subsequent interaction with its receptors, chemerin has varying degrees of bioactivity and can have pro- or anti-inflammatory roles.  It is also involved in adipogenesis, angiogenesis, skin function, obesity, glucose intolerance, cardiovascular disease, cancer, steroidogenesis, human immunodeficiency virus replication, neurogenerative disease and metabolic syndrome, as well as having a role in reproductive biology.

Further reading

De Henau (2016) Signaling Properties of Chemerin Receptors CMKLR1, GPR1 and CCRL2. PLoS One 11(10) e0164179 PMID: 27716822

Kennedy and Davenport  (2018) International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin1) and GPR1 (Chemerin2) Nomenclature, Pharmacology, and Function. Pharmacol Rev. 70(1)174 PMID: 29279348

Shin et al (2018) Mechanisms and Functions of Chemerin in Cancer: Potential Roles in Therapeutic Intervention. Front Immunol. 9 2772 PMID: 30555465