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Go 6983

Cat. No. KS-330

Structure:

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Activity:

PKC inhibitor
Price Qty
1 mg    $ 99.00

Go 6983 is a potent and broad spectrum ATP-competitive protein kinase C inhibitor, with IC50 values of 7, 7, 6, 10 and 60 nM for PKC α, β, γ, δ, ζ respectively.   Go 6983 possesses cardioprotective properties and reduces polymorphonuclear leukocyte adherence and infiltration following myocardial ischemia-reperfusion injury.  Go 6983 also optimizes naïve human pluripotent stem cell growth, and efficiently promotes the self-renewal of embryonic stem cells (ESCs).  RNA sequencing shows that the addition of Go 6983 significantly inhibits the expression of de novo methyltransferases Dnmt3a and Dnmt3b and their regulator Dnmt3l, resulting in global hypomethylation of DNA in mouse ESCs.

Gschwendt et al (1996) Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes. FEBS Lett. 392(2) 77 PMID: 8772178

Peterman et al (2004) Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J Cardiovasc Pharmacol. 43(5) 645 PMID: 15071351

Young et al (2005) Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovasc Drug Rev. 23(3):255 PMID: 16252018

Gafni et al (2013) Derivation of novel human ground state naive pluripotent stem cells. Nature 504(7479) 282 PMID: 24172903

Ji et al (2024) Inhibition of protein kinase C increases Prdm14 level to promote self-renewal of embryonic stem cells through reducing Suv39h-induced H3K9 methylation. J Biol Chem. Feb 1 105714 PMID: 38309502


Related areas

All small molecules >
All kinase inhibitors >
All transferase inhibitors >
All stem cell research categories >
All epigenetic research categories >


Technical Data

Structure 3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
CAS Number 133053-19-7
Molecular Weight 442.51
Formula C26H26N4O3

Solubility and Storage

Solubility Soluble in DMSO to 20 mg/ml
Appearance Orange solud
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity 98% by HPLC, NMR conforms

Contact Information

To place an order, or for customer services, order processing or technical support please contact us on:

UK, Europe and RoW
Tel: (+44) 01392 422205
Fax: (+44) 01392 279510
info@iscabiochemicals.com

USA and Canada

Tel: 610-994-1134

Toll Free: 855-FOCUS21 (855-362-8721)

Fax: 610-465-9100

sales@focusbiomolecules.com 


France

CliniSciences
Tel : +33 9 77 40 09 09
Fax :  +33 9 77 40 10 11
Orders and customer support : info@clinisciences.com


Germany, Switzerland, Austria

BIOZOL Diagnostics 

Tel: +49 (089) 3799 666-6

Fax: +49 (089) 3799 666-99
Orders, Technical and Customer support: info@biozol.de


Italy
Labospace
Tel: +39 02 35980841
Fax +39 02 359808004
Orders: info@labospace.com


Spain and Portugal
Abyntek Biopharma
Tel: +34 94 404 80 80

Fax: +34 94 404 80 81
Orders: info@abyntek.com


China

BIOHUB INTERNATIONAL 

上海起发实验试剂有限公司

Tel: +86-15921799099

Tel: +86-021-50724187

Fax: +86-021-50724961

Orders: sale3@78bio.com

India
BTL Biotechno Labs Pvt Ltd
Tel: +91-8860924629
07291852429
Orders, Technical and Customer support: info@biotechnolabs.com


Japan

Namiki Shoji Co.
Tel:+81-050-5527-9850
Fax:+81-3-3352-2196
email:  globalbusiness1@namiki-s.co.jp


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