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7-Transmembrane receptors
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Neuromedin U receptors
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Neuromedin S (human)
Neuromedin S (human)
Cat. No. NU-010
Structure:
H-Ile-Leu-Gln-Arg-Gly-Ser-Gly-Thr-Ala-Ala-Val-Asp-Phe-Thr-Lys-Lys-Asp-His-Thr-Ala-Thr-Trp-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2
Other Names:
NMS (human), hNMS-33
Activity:
Endogenous neuromedin U receptor agonist
Neuromedin S (human) is a 33-amino acid neuropeptide, originally isolated from rat brain as an endogenous ligand for two orphan G protein-coupled receptors FM-3/GPR66 and FM-4/TGR-1, which have since been identified as the neuromedin U receptors NMU1 and NMU2. Neuromedin S (human) shares an identical C-terminal heptapeptide with human neuromedin U, but unlike human neuromedin U, which is widely distributed in the CNS and peripheral tissues, neuromedin S (human) mainly exists in the suprachiasmatic nucleus in the CNS. Neuromedin S (human) primarily regulates biological rhythms.
Mori et al (2005) Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J. 24(2) 325 PMID: 15635449
Mitchell et al (2009) Expression and vasoconstrictor function of anorexigenic peptides neuromedin U-25 and S in the human cardiovascular system. Cardiovasc Res. 81(2) 353 PMID: 18987052
You et al (2022) Structural insights into the peptide selectivity and activation of human neuromedin U receptors. Nat Commun. 13(1) 2045 PMID: 35440625
Related areas
All peptides >
All neuromedin U receptor modulators >
All neuroscience research categories >
Technical Data
| Structure | H-Ile-Leu-Gln-Arg-Gly-Ser-Gly-Thr-Ala-Ala-Val-Asp-Phe-Thr-Lys-Lys-Asp-His-Thr-Ala-Thr-Trp-Gly-Arg-Pro-Phe-Phe-Leu-Phe-Arg-Pro-Arg-Asn-NH2 |
| CAS Number | 1138204-27-9 |
| Molecular Weight | 3789.01 |
| Formula | C173H265N53O44 |
| Sequence | ILQRGSGTAAVDFTKKDHTATWGRPFFLFRPRN-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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