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Products
Pharmacology
Type
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- Technical support
- Resources
Chemerin-9
Cat. No. CH-010
Structure:
H-Tyr-Phe-Pro-Gly-Gln-Phe-Ala-Phe-Ser-OH
Other Names:
Chemerin 149-157, Chemerin-9 (human), Chemerin C-terminal peptide
Activity:
Chemokine-like receptor 1 (CMKLR1) agonist
Chemerin-9 is a nonapeptide corresponding to amino acids 149-157 of the C terminus of processed chemerin, which retains most of the agonist activity of the full-size protein towards the chemokine-like receptor 1 (CMKLR1) with an EC50 of 7.1 nM. Chemerin-9 significantly suppresses TNF-α-induced mRNA expression of adhesion and pro-inflammatory molecules in human umbilical vein endothelial cells (HUVECs) and significantly attenuates TNF-α-induced adhesion of THP1 monocytes and the macrophage inflammatory phenotype. In Apoe -/- mice, a 4-week infusion of chemerin-9 significantly decreases aortic atherosclerotic lesions.
Wittamer et al (2004) The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem. 279(11) 9956 PMID: 14701797
Sato et al (2019) Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis. Clin Sci (Lond). 133(16) 1779 PMID: 31399499
Kasimu (2020) Regulatory effect of chemerin and therapeutic efficacy of chemerin‑9 in pancreatogenic diabetes mellitus. Mol Med Rep. 21(3) 981 PMID: 31922216
Related areas
All peptides >
All chemerin receptor modulators >
All adhesion molecule research categories >
All immunology research categories >
Technical Data
| Structure | H-Tyr-Phe-Pro-Gly-Gln-Phe-Ala-Phe-Ser-OH |
| CAS Number | 676367-27-4 |
| Molecular Weight | 1063.18 |
| Formula | C54H66N10O13 |
| Sequence | YFPGQFAFS |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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