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Products
Pharmacology
Type
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- Technical support
- Resources
Epinecidin-1
Cat. No. AM-420
Structure:
H-Gly-Phe-Ile-Phe-His-Ile-Ile-Lys-Gly-Leu-Phe-His-Ala-Gly-Lys-Met-Ile-His-Gly-Leu-Val-NH2
Other Names:
Epi-1 peptide, Synthetic epinecidin-1 (amino acid residues 22–42), EPI
Activity:
Antimicrobial peptide from orange-spotted grouper
Epinecidin-1 is a synthetic antimicrobial peptide that was originally identified from orange-spotted grouper (Epinephelus coioides). Epinecidin-1 possesses broad-spectrum antibacterial activity against Pseudomonas aeruginosa, Vibrio vulnificus, Helicobactor pylori, E. coli, and MRSA as well as antiviral activity and wound healing effects, and is also able to modulate lipoteichoic acid (LTA) induced inflammation in murine Raw 264.87 macrophages by preventing toll-like receptor internalization. In addition to its antibacterial and immunomodulatory activities, epinecidin-1 exhibits anti-cancer activity in synovial sarcoma and glioblastoma cells as an inducer of oxidative stress, and has activity aganst lung cancer.
Pan et al (2007) Gene expression and localization of the epinecidin-1 antimicrobial peptide in the grouper (Epinephelus coioides), and its role in protecting fish against pathogenic infection. DNA Cell Biol. 26(6) 403 PMID: 17570764
Lin et al (2009) Epinecidin-1, an antimicrobial peptide from fish (Epinephelus coioides) which has an antitumor effect like lytic peptides in human fibrosarcoma cells. Peptides 30(2) 283 PMID: 19007829
Chee et al (2019) Epinecidin-1, an Antimicrobial Peptide Derived From Grouper (Epinephelus coioides): Pharmacological Activities and Applications. Front Microbiol. 10 2631 PMID: 31824449
Yu et al (2023) Marine Antimicrobial Peptide Epinecidin-1 Inhibits Proliferation Induced by Lipoteichoic acid and Causes cell Death in non-small cell lung cancer Cells via Mitochondria Damage. Probiotics Antimicrob Proteins doi: 10.1007/s12602-023-10130-1. Epub ahead of print. PMID: 37523113
Related areas
All antimicrobial peptides >
All antibacterial agents >
All antiviral agents >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Gly-Phe-Ile-Phe-His-Ile-Ile-Lys-Gly-Leu-Phe-His-Ala-Gly-Lys-Met-Ile-His-Gly-Leu-Val-NH2 |
| CAS Number | 1131706-77-8 |
| Molecular Weight | 2334.88 |
| Formula | C114H176N30O21S |
| Sequence | GFIFHIIKGLFHAGKMIHGLV-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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