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Products
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- Technical support
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PACAP (6-38)
Cat. No. PA-030
Structure:
H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-OH
Other Names:
PACAP 6-38, Pituitary adenylate cyclase activating polypeptide (6-38)
Activity:
PAC1 receptor antagonist
PACAP (6-38) is a potent and competitive pituitary adenylate cyclase-activating polypeptide receptor (PAC)1 antagonist with an IC50 of 2 nM. PACAP(6–38)] is a potent mast cell degranulator and has an agonistic effect on MrgB3-receptors expressed in oocytes. PACAP (6-38) acts as a functional Cocaine- and amphetamine-regulated transcript peptides (CARTp) antagonist in vivo and blocks its effects on feeding and short term weight gain.
Leyton et al (1999) PACAP(6-38) is a PACAP receptor antagonist for breast cancer cells. Breast Cancer Res Treat. 56(2) 177 PMID: 10573110
Burgos et al (2013) Pituitary Adenylate Cyclase-Activating Polypeptide 6-38 Blocks Cocaine- and Amphetamine-Regulated Transcript Peptide-Induced Hypophagia in Rats. PLoS ONE 8(8 ) e72347 PMID: 23967296
Pedersen et al (2019) PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB3-Receptor. Front. Cellular Neuroscience 13 114 PMID: 30983973
Related areas
All peptides >
All PACAP receptor modulators >
All endocrinology research categories >
All appetite regulation research categories >
Technical Data
| Structure | H-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-OH |
| CAS Number | 143748-18-9 |
| Molecular Weight | 4024.8 |
| Formula | C182H300N56O45S |
| Sequence | FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-NH2 |
| Modifications | C terminal amide |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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