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Thanatin
Cat. No. AM-410
Structure:
H-Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-*Cys-Asn-Arg-Arg-Thr-Gly-Lys-*Cys-Gln-Arg-Met-OH (disulphide bridge between cysteines 11 and 18)
Activity:
Binds to E. Coli LptA and LptD
Thanatin is an inducible cationic antimicrobial peptide (AMP) that was first isolated from the insect Podisus maculiventris (spined soldier bug), a species of stink bug common in North America. Thanatin is a potent antibacterial and antifungal agent, with more than one mechanism of antimicrobial activity. Its antibiotic activity has been most thoroughly characterized against E. coli where it interferes with multiple pathways, including binding to the lipopolysaccharide export system proteins LptA and LptD, disrupting the lipopolysaccharide transport (LPT) complex formation and inhibiting cell wall synthesis and microbial growth. Thanatin exhibits activity against a broad range of pathogens including Gram-negative and Gram-positive bacteria and also possesses potent antifungal activity against Neurospora crassa, Botrytis cinerea, Nectria haematococca, Trichoderma viride, Alternaria brassicicola, and Fusarium culmorum.
Vetterli et al (2018) Thanatin targets the intermembrane protein complex required for lipopolysaccharide transport in Escherichia coli. Sci Adv. 4(11) eaau2634 PMID: 30443594
Dash and Bhattacharjya (2021) Thanatin: An Emerging Host Defense Antimicrobial Peptide with Multiple Modes of Action. Int J Mol Sci. 22(4) 1522 PMID: 33546369
Huynh et al (2023) Discovery, characterization, and redesign of potent antimicrobial thanatin orthologs from Chinavia ubica and Murgantia histrionica targeting E. coli LptA. J Struct Biol X. 8 100091 PMID: 37416832
Related areas
All antimicrobial peptides >
All antibacterial agents >
All antifungal agents >
All immunology research categories >
Technical Data
| Structure | H-Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-*Cys-Asn-Arg-Arg-Thr-Gly-Lys-*Cys-Gln-Arg-Met-OH (disulphide bridge between cysteines 11 and 18) |
| CAS Number | 214542-43-5 |
| Molecular Weight | 2433.93 |
| Formula | C103H177N35O27S3 |
| Sequence | GSKKPVPIIYCNRRTGKCQRM |
| Modifications | Disulphide bridge between cysteine 11 and cysteine 18 |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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