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Products
Pharmacology
Type
- News
- Custom services
- Ordering
- About Us
- Technical support
- Resources
LL 37 (13–37) (human)
Cat. No. AM-005
Structure:
H-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH
Other Names:
IG 27
Activity:
Broad spectrum antimicrobial
LL 37 (13-37) (human), also known as IG 27, is a peptide fragment composed of the C-terminal residues 13-37 of the antimicrobial peptide LL37 [AM-001]. LL37 (13-37) has been show to have antibacterial activity against E. coli, antifungal activity against C. albicans and antiviral activity, blocking the action of HIV-1 reverse transcriptase. LL 37 (13-37) is also active against cancer cells, inhibiting the proliferation of drug-resistant and drug-sensitive carcinoma cells.
Li et al (2006) Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc. 128(17) 5776 PMID: 16637646
Wu et al (2010) Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer. 127(8) 1741 PMID: 20521250
Wong et al (2011) Antifungal action of human cathelicidin fragment (LL13–37) on Candida albicans. Peptides 32(10) 1996 PMID: 21889964
Related areas
All antimicrobial peptides >
All antifungal agents >
All antiviral agents >
All immunology research categories >
All cancer research categories >
Technical Data
| Structure | H-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser-OH |
| Molecular Weight | 3043.6 |
| Formula | C137H232N42O36 |
| Sequence | IGKEFKRIVQRIKDFLRNLVPRTES |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | LL 37 (13–37) (human) MSDS_602be62774cdb.pdf |
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