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7-Transmembrane receptors
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Neuropeptide Y receptors
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Pancreatic polypeptide (human)
Pancreatic polypeptide (human)
Cat. No. NY-030
Structure:
H-Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2
Other Names:
Pancreatic polypeptide, PP
Activity:
Endogenous agonist for the human NPY Y4 receptor
Pancreatic polypeptide (human) is an endogenous high affinity agonist for the human NPY Y4 receptor, with a Ki of 0.056 nM. Pancreatic polypeptide (human) is produced and secreted by PP cells of the pancreas which are primarily located in the Islets of Langerhans and is a member of the family of peptides that includes peptide YY (PYY) and neuropeptide Y (NPY). Pancreatic polypeptide (human) is rapidly released after a meal and in humans remains elevated for 4-6 hours, with the vagus nerve being the major stimulator. Pancreatic polypeptide (human) causes a sustained decrease in both appetite and food intake.
Bard et al (1995) Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J.Biol.Chem. 270 26762 PMID: 7592911
Batterham et al (2003) Pancreatic Polypeptide Reduces Appetite and Food Intake in Humans. J. Clin. Endocrinology Metabolism 88(8) 3989 PMID: 12915697
Suzuki et al (2011) The gut hormones in appetite regulation. J Obes. 2011 528401 PMID: 21949903
Related areas
All peptides >
All neuropeptide Y receptor modulators >
All appetite regulation research categories >
Technical Data
| Structure | H-Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
| CAS Number | 75976-10-2 |
| Molecular Weight | 4181.7 |
| Formula | C185H287N53O54S2 |
| Sequence | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.70 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% |
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Recent citations
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