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7-Transmembrane receptors
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Corticotropin releasing factor receptors
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α-helical CRF (9-41)
α-helical CRF (9-41)
Cat. No. CR-010
Structure:
H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2
Other Names:
α-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9–41)
Activity:
CRF antagonist
α-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2α and mouse CRF2β receptors respectively. α-helical CRF (9-41) decreases anxiety like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. α-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition.
Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology 2 285 PMID: 2610824
Skórzewska et al (2009). The effect of CRF and α-helical CRF(9–41) on rat fear responses and amino acids release in the central nucleus of the amygdala. Neuropharmacology 57(2) 148 PMID: 19477189
Smedh et al (2019) Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide. BMC Neurosci 20 11 PMID: 30885137
Related areas
All peptides >
All corticotropin releasing factor receptor modulators >
All endocrinology categories >
All neuroscience categories >
All appetite regulation categories >
Technical Data
| Structure | H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2 |
| CAS Number | 90880-23-2 |
| Molecular Weight | 3827 |
| Formula | C166H274N46O53S2 |
| Sequence | DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in 0.1% TFA |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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