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7-Transmembrane receptors
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Angiotensin receptors

Angiotensin receptors

The angiotensin family of peptides is important in the regulation of blood volume, vascular resistance and electrolyte balance.  Angiotensin II, the main peptide of the renin-angiotensin system is produced in a cascade whereby the precursor peptide angiotensinogen is cleaved to produce renin and angiotensin I.  Angiotensin-converting enzyme then acts on angiotensin I to yield the octapeptide angiotensin II, and further processing generates angiotensin III and IV.  These peptides act on three angiotensin receptor subtypes, AT1, AT2 and AT4.  The actions of angiotensin II are primarily mediated by AT1, whereas AT2 preferentially binds angiotensin III and AT4 is selective for angiotensin IV.
Peptides
Cat No. Product Name Activity
NR-160 Angiotensin (1-7) Endogenous angiotensin peptide fragment
AT-010 Angiotensin II Endogenous vasoconstrictor hormone
NR-170 Saralasin Angiotensin II receptor partial agonist 
AT-020 Sarilesin Angiotensin receptor antagonist

Further reading

Oliverio and Coffman (1997)  Angiotensin‐II receptors: new targets for antihypertensive therapy. Clin. Cardiol. 20 3 PMID: 8994730

Deshayes and Nahmias (2005) Angiotensin receptors: a new role in cancer?, Trends Endocrinol. Metab. 16(7) 293 PMID: 16061390

Singh and Karnik (2016). Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications. J. Cell Signal. 1(2) 111 PMID: 27512731




Related Targets

Peptide receptors

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