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7-Transmembrane receptors
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Angiotensin II
Angiotensin II
Cat. No. AT-010
Structure:
H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Other Names:
Ang II
Activity:
Endogenous vasoconstrictor hormone
Angiotensin II (Ang II) is an endogenous active peptide of the renin-angiotensin system. Angiotensin II is produced from angiotensin I through the removal of two C-terminal residues by angiotensin converting enzyme (ACE), primarily within the lung. Angiotensin II binds to AT1 and AT2 receptors and plays a central role in the regulation of blood pressure and electrolyte homeostasis. Angiotensin II also mediates vasoconstriction, thirst, release of vasopressin and aldosterone, renal sodium reabsorption, fibrosis, inflammation, angiogenesis, vascular aging, and atherosclerosis.
Fyhrquist et al (1995) Role of angiotensin II in blood pressure regulation and in the pathophysiology of cardiovascular disorders. J Hum Hypertens. Suppl 5 S19-24. PMID: 8583476
Potts et al (1999) Activation of brain neurons by circulating angiotensin II: direct effects and baroreceptor-mediated secondary effects. Neuroscience 90(2) 581 PMID: 10215161
Cheng et al (2005) Angiotensin II and Vascular Inflammation. Med Sci Monit. 11(6) RA194 PMID: 15917731
Related areas
All peptides >
All angiotensin receptor modulators >
All endocrinology research categories >
All cardiovascular research categories >
Technical Data
| Structure | H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH |
| CAS Number | 4474-91-3 |
| Molecular Weight | 1046.2 |
| Formula | C50H71N13O12 |
| Sequence | DRVYIHPF |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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