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PD 325901
Cat. No. KS-310
Structure:
N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Activity:
MEK inhibitor
PD 0325901 is a potent MEK1 and MEK2 inhibitor, which inhibits MEK activity in mouse colon cells with an IC50 of 0.33 nM. PD 0325901 inhibits growth and proliferation of a variety of cancer cells in vitro, also inhibiting production of proangiogenic cytokines such as VEGF. In vivo, PD 032901 induces G1-phase cell cycle arrest and apoptosis in a cancer model and promotes myelin recovery in drug-induced demyelination in vivo in mice. PD 0325901 enhances generation of induced pluripotent stem cells (iPSCs) and in combination with CHIR 99021 and A 83-01 induces generation of ground state iPS cells from human and rat somatic cells.
Barrett et al (2008) The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 18(24) 6501 PMID: 18952427
Ciuffreda et al (2009) Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations. Neoplasia 11(8) 720 PMID: 19649202
Ai et al (2016) Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901. Stem Cells Int. 2016:1792573 PMID: 26770202
Suo et al (2019) Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia 67(7) 1320 PMID: 30815939
Kim and Breton (2022) The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis. Biol Reprod. 106(5) 919 PMID: 3515611
Related areas
All small molecules >
All kinase modulators >
All cancer research categories >
All stem cell research categories >
Technical Data
| Structure | N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide |
| CAS Number | 391210-10-9 |
| Molecular Weight | 482.2 |
| Formula | C16H14F3IN2O4 |
Solubility and Storage
| Solubility | Soluble in DMSO to 20 mg/ml or ethanol to 20 mg/ml. |
| Appearance | White solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | 98% by hplc. NMR conforms |
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