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Products
Pharmacology
Type
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- Technical support
- Resources
CHIR 99021
Cat. No. KS-260
Structure:
6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
Other Names:
CT99021, Laduviglusib
Activity:
GSK3 inhibitor
CHIR 99021 is a potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3), with IC50 values of 6.7 and 10 nM for GSK-3β and GSK-3α respectively, and greater than >500-fold selectivity for GSK-3 over closely related kinases. CHIR 99021 in combination with other agents can be used to reprogram mouse embryonic fibroblasts into induced pluripotent stem cells (iPSCs) and can also enhance mouse and human embryonic stem cell (ESC) self-renewal and promote differentiation of human pluripotent stem cells (hPSCs) in cardiomyocytes. CHIR 99021 is used in a protocol to generate brain organoids from human iPSCs.
Ring (2003) Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes 52(3) 588 PMID: 12606497
Seong et al (2022) Epiblast inducers capture mouse trophectoderm stem cells in vitro and pattern blastoids for implantation in utero. Cell Stem Cell 29(7) 1102 PMID: 35803228
Schafer et al (2023) An in vivo neuroimmune organoid model to study human microglia phenotypes. 186(10) 2111 PMID: 37172564
Related areas
All small molecules >
All kinase modulators >
All stem cell research categories >
Technical Data
| Structure | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile |
| CAS Number | 252917-06-9 |
| Molecular Weight | 465.35 |
| Formula | C22H18Cl2N8 |
Solubility and Storage
| Solubility | Soluble in DMSO to 25 mg/ml |
| Appearance | White solid |
| Storage | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Batch Specific Data
| Purity | 99% by TLC, NMR conforms |
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Recent citations
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