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Etomoxir

Cat. No. TR-010

Structure:

(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt

Other Names:

(R)-(+)-Etomoxir

Activity:

Carnitine palmitoyltransferase inhibitor
Price Qty
5 mg    $ 115.00

Etomoxir is an irreversible inhibitor of mitochondrial carnitine palmitoyl transferase 1 (CPT1).  Etomoxir inhibits β-oxidation in mitochondria and also inhibits cardiolipin biosynthesis from exogenous fatty acid in H9c2 cells, and is widely used to study fatty acid oxidation.  Etomoxir has been investigated as a therapeutic agent for heart disease, diabetes, and cancer.

Agius et al (1991) Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem Pharmacol. 42(9) 1717 PMID: 1930298

Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J.6(6) 2349 PMID: 1531968

Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 44(2) 415 PMID: 12576524

Pike et al (2011) Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta. 1807(6) 726 PMID: 21692241

Yao et al (2018) Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. PLoS Biol. 16(3) e2003782 PMID: 29596410


Related areas 

All small molecules >
All transferase modulators >
All cardiovascular research categories >
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Technical Data

Structure (R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
CAS Number 828934-41-4
Molecular Weight 320.74
Formula C15H18ClO4 • Na

Solubility and Storage

Solubility Soluble to 5mg per ml in water
Appearance White solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity 98% by HPLC, NMR conforms

Contact Information

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