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Products
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EPI-X4
Cat. No. CK-030
Structure:
H-Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu-OH
Other Names:
Endogenous peptide inhibitor of CXCR4, hSA(408–423) peptide
Activity:
Endogenous
CXCR4 antagonist
EPI-X4 (endogenous peptide inhibitor of CXCR4) is a fragment identified from a blood-derived peptide library, corresponding to residues 408–423 of human serum albumin
(hSA). EPI-X4 is a highly specific endogenous
CXCR4 antagonist which is evolutionarily conserved and generated
from the albumin precursor by
pH-regulated proteases under acidic conditions that are a
hallmark of inflammation. EPI-X4 suppresses CXCR4 signaling and inhibits
infection by CXCR4 tropic HIV-1 strains. EPI-X4 can also antagonize CXCL12-induced
tumour cell migration, mobilise stem cells and suppress inflammatory responses in mice. EPI-X4 is abundant in the urine
of patients with inflammatory kidney diseases and
may serve as a biomarker.
Zirafi et al (2015) Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 11(5) 737 PMID: 25921529
Müller et al (2016) Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. 51(8) 1137 PMID: 27042833
Gaonkar et al (2023) Development of a New Class of CXCR4-Targeting Radioligands Based on the Endogenous Antagonist EPI-X4 for Oncological Applications. J Med Chem. 66(13) 8484 PMID: 37328158
Related areas
All peptides >
All chemokine receptors >
All antivirals >All immunology research categories >
Technical Data
| Structure | H-Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu-OH |
| Molecular Weight | 1830.20 |
| Formula | C84H144N22O23 |
| Sequence | LVRYTKKVPQVSTPTL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
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