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YHIEPV

Cat. No. CY-050

Structure:

H-Tyr-His-Ile-Glu-Pro-Val-OH

Other Names:

rALP-2, Rubisco anxiolytic-like peptide 2

Activity:

Increases neural leptin responsiveness
Price Qty
1 mg    $ 99.00

YHIEPV is a peptide derived from pepsin-pancreatin digestion of the green leaf protein rubisco, the storage protein which plays a key role in carbon dioxide fixation and photorespiration.  YHIEPV corresponds to the rubisco large subunit (85-90) and exhibits anxiolytic like effects after oral administration, which are mediated through activation of the δ-opioid receptor.  In vitro, YHIEPV increases leptin induced phosphorylation of STAT3 and mitigates palmitic acid induced decreases in leptin responsiveness, and in obese mice, YHIEPV promotes leptin induced reductions in body weight and food intake.

Kimura et al (2018) Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest. Biochem Biophys Res Commun. 505(4) 1050 PMID: 30314694

Kaneko et al (2022) An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness. Sci Rep. 12(1) 8599 PMID: 35597815


Related areas

All peptides >
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All appetite regulation research categories >
All plant science products >


Technical Data

Structure H-Tyr-His-Ile-Glu-Pro-Val-OH
Molecular Weight 756.38
Formula C36H52N8O10
Sequence YHIEPV
Modifications None

Solubility and Storage

Solubility Soluble in water
Appearance Freeze dried solid
Storage Store dry, frozen and in the dark

Batch Specific Data

Purity >95% by hplc

Contact Information

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BIOZOL Diagnostics 

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Italy
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Abyntek Biopharma
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BIOHUB INTERNATIONAL 

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