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Products
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- Technical support
- Resources
YHIEPV
Cat. No. CY-050
Structure:
Other Names:
Activity:
YHIEPV is a peptide derived from pepsin-pancreatin digestion of the green leaf protein rubisco, the storage protein which plays a key role in carbon dioxide fixation and photorespiration. YHIEPV corresponds to the rubisco large subunit (85-90) and exhibits anxiolytic like effects after oral administration, which are mediated through activation of the δ-opioid receptor. In vitro, YHIEPV increases leptin induced phosphorylation of STAT3 and mitigates palmitic acid induced decreases in leptin responsiveness, and in obese mice, YHIEPV promotes leptin induced reductions in body weight and food intake.
Kimura et al (2018) Identification of Rubisco anxiolytic-like peptides (rALPs) by comprehensive analysis of spinach green leaf protein digest. Biochem Biophys Res Commun. 505(4) 1050 PMID: 30314694
Kaneko et al (2022) An orally active plant Rubisco-derived peptide increases neuronal leptin responsiveness. Sci Rep. 12(1) 8599 PMID: 35597815
Related areas
All peptides >
All cytokine receptor modulators >
All δ opioid receptor modulators >
All appetite regulation research categories >
All plant science products >
Technical Data
Structure | H-Tyr-His-Ile-Glu-Pro-Val-OH |
Molecular Weight | 756.38 |
Formula | C36H52N8O10 |
Sequence | YHIEPV |
Modifications | None |
Solubility and Storage
Solubility | Soluble in water |
Appearance | Freeze dried solid |
Storage | Store dry, frozen and in the dark |
Batch Specific Data
Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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