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Staurosporine
Cat. No. KS-320
Structure:
[9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
Other Names:
AM 2282
Activity:
Broad spectrum kinase inhibitor
Staurosporine is a broad spectrum kinase inhibitor, inhibiting protein kinase C, p60v-src tyrosine kinase, protein kinase A, and CaM kinase II with IC50 values of 3nM, 6 nM, 7 nM and 20 nM respectively. Staurosporine reduces nuclear myosin heavy chain 9 phosphorylation which inhibits gastric cancer cell progression in transgenic mouse models. Staurosporine inhibits cell viability and promotes apoptosis in oral and pancreatic cancer cells. Staurosporine also enhances efficiency of lentiviral transduction of human hematopoietic stem and progenitor cells, induces dopaminergic axonal outgrowth in vitro and triggers mitophagy.
Omura (1977) A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization. J Antibiot (Tokyo) 30(4) 275 PMID: 863788
Rüegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases. Trends Pharmacol Sci. 10(6) 218 PMID: 2672462
Lewis et al (2018) Staurosporine Increases Lentiviral Vector Transduction Efficiency of Human Hematopoietic Stem and Progenitor Cells. Mol Ther Methods Clin Dev. 9 313 PMID: 30038935
Malsy et al (2019) Staurosporine induces apoptosis in pancreatic carcinoma cells PaTu 8988t and Panc-1 via the intrinsic signaling pathway. Eur J Med Res. 24(1) 5 PMID: 30686270
Ye et al (2020) Nuclear MYH9-induced CTNNB1 transcription, targeted by staurosporin, promotes gastric cancer cell anoikis resistance and metastasis. Theranostics 10(17) 7545 PMID: 32685004
Related areas
All small molecules >
All kinase modulators >
All receptor tyrosine kinase modulators >
All cancer research categories >
All stem cell research categories >
Technical Data
| Structure | [9S-(9α,10β,11β,13α)]-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one |
| CAS Number | 62996-74-1 |
| Molecular Weight | 466.53 |
| Formula | C28H26N4O3 |
Solubility and Storage
| Solubility | Soluble in DMSO to 25 mg/ml |
| Appearance | Off white to pale yellow solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >98% by tlc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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