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7-Transmembrane receptors
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Neuropeptide FF receptors
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Neuropeptide FF
Neuropeptide FF
Cat. No. NF-010
Structure:
H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2
Other Names:
NPFF
Activity:
Endogenous NPFF1 and NPFF2 agonist
Neuropeptide FF is an endogenous agonist at NPFF1 and NPFF2 receptors with Ki values of 2.82 and 0.21 nM respectively. Neuropeptide FF belongs to the RFamide family of peptides that are involved in a wide variety of physiological functions including central cardiovascular and neuroendocrine regulation. Neuropeptide FF also plays a role in pain regulation, modulation of opioid side effects, drug reward and anxiety.
Cline et al (2007) Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 41(6) 433 PMID: 17936900
Jhamandas and Goncharuk (2013) Role of neuropeptide FF in central cardiovascular and neuroendocrine regulation. Front Endocrinol. 4 8 PMID: 23404625
Nguyen et al (2020) Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. J Med Chem. 63(21) 12387 PMID: 32673481
Related areas
All peptides >
All neuropeptide FF receptor modulators >
All endocrinology research areas >
All cardiovascular research areas >
All pain research areas >
All neuroscience research areas >
Technical Data
| Structure | H-Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 |
| CAS Number | 99566-27-5 |
| Molecular Weight | 1081.28 |
| Formula | C54H76N14O10 |
| Sequence | FLFQPQRF-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 0.50 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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