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WRW4
Cat. No. FR-020
Structure:
H-Trp-Arg-Trp-Trp-Trp-Trp-NH2
Activity:
Selective formyl peptide receptor 2 (FPR2) antagonist
WRW4 is a selective antagonist of formyl peptide receptor 2 (FPR2) signaling, which can inhibit WKYMVm binding to FPR2 with an C50 of 0.23 μM and can also inhibit intracellular calcium release induced by WKYMVm, MMK 1, amyloid β42, and F peptide. WRW4 inhibits FPR2-mediated signaling in human neutrophils and blocks chemotactic migration and superoxide generation by amyloid β42 peptide. WRW4 can reduce Brucella proliferation in animal models.
Bae et al (2004) Identification of peptides that antagonize formyl peptide receptor-like 1-mediating signaling. J.Immunol. 173 607 PMID: 15210823
Kain et al (2018), Inhibition of FPR2 Impaired Leukocyte Get‐in Signal and Triggers Non‐Resolving Inflammation in Heart Failure. FASEB J. 32 287 PMID: 31216426
Reyes et al (2021) Formyl peptide receptor 2 (FPR2) antagonism is a potential target for the prevention of Brucella abortus 544 infection, Immunobiology 226(3) 152073 https://doi.org/10.1016/j.imbio.2021.152073
Related areas
All peptides >
All formyl peptide receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Trp-Arg-Trp-Trp-Trp-Trp-NH2 |
| CAS Number | 878557-55-2 |
| Molecular Weight | 1104.28 |
| Formula | C61H65N15O6 |
| Sequence | WRWWWW-NH2 |
| Modifications | C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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