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Products
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WKYMVm
Cat. No. FR-010
Structure:
H-Trp-Lys-Tyr-Met-Val-D-Met-NH2
Other Names:
Leukocyte chemoattractant peptide
Activity:
FPR1, FPR2 and FPR3 receptor agonist
WKYMVm is a selective agonist for formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) when expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. WKYMVm has pleiotropic anti-inflammatory, pro-angiogenic, anti-apoptotic and immunomodulatory effects in various animal models of sepsis, ulcerative colitis, myocardial infarction, ischemic hindlimb and diabetic cutaneous wound healing.
Christophe et al (2001) The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/Lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J.Biol.Chem. 276 21585 PMID: 11285256
Shin (2005) The Synthetic Chemoattractant Peptide WKYMVm Induces Superoxide Production by Human Eosinophils via the Phosphoinositide 3-Kinase-Mediated Activation of ERK1/2. Int Arch Allergy Immunol. 137(suppl 1) 21 PMID: 15947481
Kim et al (2019) WKYMVm hexapeptide, a strong formyl peptide receptor 2 agonist, attenuates hyperoxia-induced lung injuries in newborn mice. Sci Rep 9 6815 PMID: 31048743
Related areas
All peptides >
All formyl peptide receptor modulators >
All immunology research categories >
Technical Data
| Structure | H-Trp-Lys-Tyr-Met-Val-D-Met-NH2 |
| CAS Number | 187986-17-0 |
| Molecular Weight | 856.11 |
| Formula | C41H61N9O7S2 |
| Sequence | WKYMVm-NH2 |
| Modifications | Methionine 6 is D-Met, C-terminal amide |
Solubility and Storage
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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