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7-Transmembrane receptors
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[Leu5]-Enkephalin
[Leu5]-Enkephalin
Cat. No. DR-020
Structure:
H-Tyr-Gly-Gly-Phe-Leu-OH
Other Names:
ICI 114740, Dynorphin-(1-5), Leu-enkephalin, Leu5-enkephalin
Activity:
Endogenous μ- and δ-opioid receptor agonist
[Leu5]-Enkephalin is an endogenous opioid peptide neurotransmitter that is found in the brains of many animals including humans. [Leu5]-Enkephalin is one of the two forms of enkephalin; the other being met-enkephalin. The tyrosine residue at position 1 is analogous to the 3-hydroxyl group on morphine and [Leu5]-enkephalin acts as an agonist at both μ- and δ-opioid receptors, with greater preference for δ and little to no effect on the κ-opioid receptor.
Meunier et al (1977) Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 77 209 PMID: 862920
Porreca et al (1990) Modulation of morphine antinociception by peripheral [Leu5]enkephalin: a synergistic interaction. Eur J Pharmacol. 179(3) 463 PMID: 2364995
Cheng et al (1996) Immunolabeling of mu opioid receptors in the rat nucleus of the solitary tract: extrasynaptic plasmalemmal localization and association with Leu5-enkephalin. J. Comp. Neurol. 371 522 PMID: 8841907
Related areas
All peptides >
All δ opioid receptor modulators >
All μ opioid receptor modulators >
All pain research categories >
Technical Data
| Structure | H-Tyr-Gly-Gly-Phe-Leu-OH |
| CAS Number | 58822-25-6 |
| Molecular Weight | 555.63 |
| Formula | C28H37N5O7 |
| Sequence | YGGFL |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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