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7-Transmembrane receptors
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Parathyroid hormone receptors
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Parathyroid hormone (1-34) (human)
Parathyroid hormone (1-34) (human)
Cat. No. PH-010
Structure:
H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH
Other Names:
PTH 1-34, hPTH (1-34), Teriparatide, Human parathyroid hormone (1-34)
Activity:
Parathyroid hormone receptor agonist
Parathyroid hormone (1-34) (human), also known as teriparatide or (PTH 1-34) is the N-terminal fragment of the intact hormone human parathyroid hormone (PTH), an 84-amino acid polypeptide secreted from the parathyroid gland. Intermittently administered parathyroid hormone (PTH 1-34) has been shown to promote bone formation in both human and animal studies. Parathyroid and its analogues stimulate both bone formation and resorption, and at low doses are in clinical use for the treatment of severe osteoporosis.
Dobnig and Turner (1997) The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats. Endocrinology 138 4607 PMID: 9348185
Manabe et al (2007) Human parathyroid hormone (1-34) accelerates natural fracture healing process in the femoral osteotomy model of cynomolgus monkeys. Bone 40 1475 PMID: 17369013
Osagie-Clouard et al (2017) Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res. 6(1) 14 PMID: 28062525
Related areas
All peptides >
All parathyroid hormone receptor modulators >
All endocrinology research categories >
Technical Data
| Structure | H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH |
| CAS Number | 52232-67-4 |
| Molecular Weight | 4117.77 |
| Formula | C181H291N55O51S2 |
| Sequence | SVSEIQLMHNLGKHLNSMERVEWLRKKLQDVHNF |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble to 0.40 mg/ml in water |
| Appearance | Freeze fried solid |
| Storage | Store in the dark, frozen and dessicated |
Batch Specific Data
| Purity | >95% |
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