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Products
Pharmacology
Type
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- Ordering
- About Us
- Technical support
- Resources
Nitazoxanide
Cat. No. CV-020
Structure:
O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate
Other Names:
NTZ
Activity:
Broad spectrum antiparasitic and antiviral
Nitazoxanide is a broad-spectrum antiparasitic and broad-spectrum antiviral drug that is used clinically in the treatment of various helminthic, protozoal, and viral infections. The anti-protozoal activity of nitazoxanide is due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction required for anaerobic energy metabolism. As an antiviral agent nitazoxanide is active against many RNA and DNA viruses including influenza, hepatitis B and C, RSV and dengue and shows inhibitory efficacy against the coronavirus protease in vitro.
Sisson et al (2002) Enzymes associated with reductive activation and action of nitazoxanide, nitrofurans, and metronidazole in Helicobacter pylori. Antimicrob. Agents Chemother. 46(7) 2116 PMID: 12069963
Di Santo and Ehrisman (2013) Research perspective: potential role of nitazoxanide in ovarian cancer treatment. Old drug, new purpose? Cancers 5(3) 1163 PMID: 24202339
Liu et al (2020) Research and Development on Therapeutic Agents and Vaccines for COVID-19 and Related Human Coronavirus Diseases. ACS Cent. Sci. 6(3) 315 PMID: 32226821
Related areas
All small molecules >
All antiviral agents >
All antiparasitic agents >
Technical Data
| Structure | O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate |
| CAS Number | 55981-09-4 |
| Molecular Weight | 307.3 |
| Formula | C12H9N3O5S |
| Sequence | O-[N-(5-Nitrothiazol-2-yl)carbamoyl]phenyl acetate |
Solubility and Storage
| Solubility | Soluble in DMSO to 50mg/ml |
| Appearance | Off-white powder |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by hplc, NMR conforms to standard |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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