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Products
Pharmacology
Type
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- Custom services
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- Technical support
- Resources
Candidalysin
Cat. No. AM-390
Structure:
H-Ser-Ile-Ile-Gly-Ile-Ile-Met-Gly-Ile-Leu-Gly-Asn-Ile-Pro-Gln-Val-Ile-Gln-Ile-Ile-Met-Ser-Ile-Val-Lys-Ala-Phe-Lys-Gly-Asn-Lys-OH
Other Names:
Ece1-III62–92K , CL
Activity:
Fungal cytolytic peptide toxin from Candida albicans
Candidalysin is a peptide generated by kexin-like proteinase posttranslational processing of the 271-amino-acid preproprotein Ece1p, and is the dominant peptide secreted by the pathogen Candida albicans hyphae during mucosal infection. Candidalysin is a cytolytic peptide toxin that causes epithelial cell damage and activates downstream inflammatory responses inducing c-Fos, p-MKP1, cytokines (IL-1α, G-CSF) and calcium influx. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is a classical virulence factor of C. albicans but also triggers protective immune responses in the host organism. C. albicans strains lacking candidalysin do not activate or damage epithelial cells and are avirulent in animal models of mucosal infection.
Moyes et al (2016) Candidalysin is a fungal peptide toxin critical for mucosal infection. Nature 532(7597) 64 PMID: 27027296
Naglik et al (2019) Candidalysin: discovery and function in Candida albicans infections. Curr Opin Microbiol. 52 100 PMID: 31288097
Hu et al (2023) Candidalysin amplifies the immune inflammatory response in Candida albicans keratitis through the TREM-1/DAP12 pathway. Int Immunopharmacol. 119 110195 PMID: 37087869
Related areas
All peptides >
All fungal agents >
All immunology research categories >
Technical Data
| Structure | H-Ser-Ile-Ile-Gly-Ile-Ile-Met-Gly-Ile-Leu-Gly-Asn-Ile-Pro-Gln-Val-Ile-Gln-Ile-Ile-Met-Ser-Ile-Val-Lys-Ala-Phe-Lys-Gly-Asn-Lys-OH |
| CAS Number | 1906866-53-2 |
| Molecular Weight | 3310.16 |
| Formula | C153H266N38O38S2 |
| Sequence | SIIGIIMGILGNIPQVIQIIMSIVKAFKGNK |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
| Safety Data Sheet | AM-390 Candidalysin SDS_66bddff1aa195.pdf |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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