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RsAFP2
Cat. No. AM-140
Structure:
PyroGlu-Lys-Leu-Cys-Gln-Arg-Pro-Ser-Gly-Thr-Trp-Ser-Gly-Val-Cys-Gly-Asn-Asn-Asn-Ala-Cys-Lys-Asn-Gln-Cys-Ile-Arg-Leu-Glu-Lys-Ala-Arg-His-Gly-Ser-Cys-Asn-Tyr-Val-Phe-Pro-Ala-His-Lys-Cys-Ile-Cys-Tyr-Phe-Pro-Cys-OH (disulphide bridges between cysteines 4-51, 15-36, 21-45 and 25-47)
Other Names:
Raphanus sativus antifungal peptide 2
Activity:
Antifungal plant defensin isolated from radish seeds
RsAFP2, or raphanus sativus antifungal peptide 2, is an an antifungal plant defensin isolated from seeds of the radish, raphanus sativus, which interacts with glucosylceramides (GlcCer) in the membranes of susceptible yeast and fungi to induce membrane permeabilization and fungal cell death. RsAFP2 is active against Candida albicans and inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. In animal models, RsAFP2 is prophylactically effective against murine candidiasis.
Aerts et al (2007) The Antifungal Activity of RsAFP2, a Plant Defensin from Raphanus sativus, Involves the Induction of Reactive Oxygen Species in Candida albicans. J. Mol. Microbiol. Biotechnol. 13 243 PMID: 17827975
Bergter et al (2008) In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis. Antimicrob. Agents Chemother. 52(12) 4522 PMID: 18824606
Thevissen et al (2012), The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Mol. Microbiol. 84 166 PMID: 22384976
Related areas
All antimicrobial peptides >
All antifungal agents >
All immunology research areas >
All plant science products >
Technical Data
| Structure | PyroGlu-Lys-Leu-Cys-Gln-Arg-Pro-Ser-Gly-Thr-Trp-Ser-Gly-Val-Cys-Gly-Asn-Asn-Asn-Ala-Cys-Lys-Asn-Gln-Cys-Ile-Arg-Leu-Glu-Lys-Ala-Arg-His-Gly-Ser-Cys-Asn-Tyr-Val-Phe-Pro-Ala-His-Lys-Cys-Ile-Cys-Tyr-Phe-Pro-Cys-OH (disulphide bridges between cysteines 4-51, 15-36, 21-45 and 25-47) |
| Molecular Weight | 5710.6 |
| Formula | C244H368N76O68S8 |
| Sequence | PyroGlu-KLCQRPSGTWSGVCGNNNACKNQCIRLEKARHGSCNYVFPAHKCICYFPC |
| Modifications | Disulphide bridges between cysteines 4-51, 15-36, 21-45 and 25-47 |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dark, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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