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Products
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Histatin 5
Cat. No. AM-091
Structure:
H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH
Activity:
Antimicrobial peptide found in saliva
Histatin 5 is a 24 amino acid histidine-rich cationic salivary peptide, formed with histatin 8 from post-translational cleavage of histatin 3. Histatins function as antimicrobial peptides and are important components of the innate immune system. Histatin 5 has broad spectrum antimicrobial action including activity against gram positive and gram negative bacteria, and fungi including Candida albicans and Aspergillus fumigans. Histatin 5 antifungal activity is caused by disruption to mitochondrial respiration through reactive oxygen species (ROS) production.
Mochon and Liu (2008) The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm. PLoS Pathog. 4(10) e1000190 PMID: 18974864
Oudhoff et al (2008) Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. 22(11) 3805 PMID: 18650243
Hemadi et al (2017) Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int. J. Oral Sci. 9, e1 PMID: 29125139
Related areas
All antimicrobial peptides >
All antifungal agents >
All immunology research categories >
Technical Data
| Structure | H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH |
| CAS Number | 104339-66-4 |
| Molecular Weight | 3036.3 |
| Formula | C133H195N51O33 |
| Sequence | DSHAKRHHGYKRKFHEKHHSHRGY |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | Histatin 5 MSDS_602bc0eb0c9a2.pdf |
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