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Products
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- Technical support
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BMAP 28 (bovine)
Cat. No. AM-030
Structure:
H-Gly-Gly-Leu-Arg-Ser-Leu-Gly-Arg-Lys-Ile-Leu-Arg-Ala-Trp-Lys-Lys-Tyr-Gly-Pro-Ile-Ile-Val-Pro-Ile-Ile-Arg-Ile-Gly-OH
Activity:
Bovine myeloid cathelicidin with activitiy against bacteria and fungi
BMAP 28 is a 28 amino acid bovine myeloid cathelicidin exhibiting multiple activities against bacteria and fungi. BMAP 28 has an alpha helical structure and this acts to disrupt cell membranes, and can inhibit pan-drug-resistant Acinetobacter baumannii (PDRAB) though interaction with its outer membrane proteins (OMPs). It can also induce membrane permeabilization and death in human tumour cell lines.
Risso et al (2002) BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol. Cell. Biol. 22(6) 1926 PMID: 11865069
Brogden et al (2007) Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific. Vet. Microbiol. 119 76 PMID: 16997510
Guo et al (2018) A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine 97(42), e12832 PMID: 30334982
Related areas
All antimicrobial peptides >
All antifungal agents >
All cancer research categories >
All immunology research categories >
Technical Data
| Structure | H-Gly-Gly-Leu-Arg-Ser-Leu-Gly-Arg-Lys-Ile-Leu-Arg-Ala-Trp-Lys-Lys-Tyr-Gly-Pro-Ile-Ile-Val-Pro-Ile-Ile-Arg-Ile-Gly-OH |
| Molecular Weight | 3131.9 |
| Formula | C147H252N44O31 |
| Sequence | GGLRSLGRKILRAWKKYGPIIVPIIRIG |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in dilute acid |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and desiccated |
Batch Specific Data
| Purity | >95% by HPLC |
| Safety Data Sheet | BMAP 28 (bovine) MSDS_602baa7b3de6f.pdf |
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