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Products
Pharmacology
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- About Us
- Technical support
- Resources
Nafamostat mesylate
Cat. No. PI-040
Structure:
4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Activity:
Serine protease inhibitor
Nafamostat mesylate is a serine protease inhibitor. It inhibits a large number of Lys/Arg specific serine proteinases, and is also a tryptase inhibitor. In vivo nafamostat is a fast-acting proteolytic inhibitor and used during hemodialysis to prevent the proteolysis of fibrinogen into fibrin. Nafamostat also has some antiviral and anti-cancer properties and has been identified as a potential treatment for COVID-19.
Sendo et al (2003) A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br. J. Pharmacol. 138 959 PMID: 12642398
Chen et al (2006) Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J. Allergy Clin. Immunol. 118 105 PMID: 16815145
Wang et al (2020) Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. 30(3) 269 PMID: 32020029
Related areas
All small molecules >
All serine protease modulators >
All antiviral agents >
All cancer research categories >
Technical Data
| Structure | 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate |
| CAS Number | 82956-11-4 |
| Molecular Weight | 539.59 |
| Formula | C19H17N5O2.2CH4O3S |
| Sequence | 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate |
Solubility and Storage
| Solubility | Soluble to 100 mM in water |
| Appearance | White solid |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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