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Products
Pharmacology
Type
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- About Us
- Technical support
- Resources
Camostat mesylate
Cat. No. CV-001
Structure:
4-2-2-dimethylamino-2-oxoethoxy-2-oxoethylphenyl 4-guanidinobenzoate, methanesulfonic acid salt
Activity:
Serine protease inhibitor
Camostat is an orally active serine protease inhibitor which can inhibit plasmin, kallikrein, thrombin and trypsin, and attenuate pancreatic fibrosis in vivo. Camostat also inhibits influenza virus replication in human tracheal epithelial cells and reduces infection of Calu-3 lung cells by SARS-CoV-2 through inhibition of the serine protease TMPRSS2, required for viral spike protein priming. In mice, camostat was effective in protecting against death following a lethal SARS-CoV infection, with a survival rate of 60%.
Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. 80 1999 PMID: 17433371
Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell 181 271 PMID: 32142651
Uno (2020) Camostat mesilate therapy for COVID-19. Intern. Emerg. Med. Apr 29 1 doi: 10.1007/s11739-020-02345-9. Epub ahead of print. PMID: 32347443
Related areas
All small molecules >
All serine protease modulators >
All antiviral agents >
Technical Data
| Structure | 4-2-2-dimethylamino-2-oxoethoxy-2-oxoethylphenyl 4-guanidinobenzoate, methanesulfonic acid salt |
| CAS Number | 59721-29-8 |
| Molecular Weight | 494.5 |
| Formula | C20H22N4O5 CH3SO3H |
| Sequence | 4-2-2-dimethylamino-2-oxoethoxy-2-oxoethylphenyl 4-guanidinobenzoate, methanesulfonic acid salt |
Solubility and Storage
| Solubility | Soluble in water and DMSO to 50mg/ml |
| Appearance | Off-white powder |
| Storage | Store desiccated, frozen and in the dark |
Batch Specific Data
| Purity | >98% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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