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Products
Pharmacology
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- Technical support
- Resources
Tat-beclin 1
Cat. No. PP-200
Structure:
H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH
Other Names:
Tat-BECN1, Beclin-1 Activator I, beclin 1 peptide
Activity:
Autophagy inducing peptide
Tat-beclin 1 is a cell permeable peptide derived from the domain of the autophagy protein beclin 1 that interacts with HIV-1 Nef, attached to the HIV-1 Tat protein transduction domain. Tat-beclin 1 activates beclin1 by competing against its negative regulator GAPR-1/glioma pathogenesis-related protein-2 (GLIPR2). Tat-beclin 1 suppresses the accumulation of htt103Q, a polyglutamine expansion protein derived from human mutant Huntingtin protein, and can inhibit the replication of pathogens including HIV-1 and West Nile virus in vitro and in vivo.
Shoji-Kawata et al (2013) Identification of a candidate therapeutic autophagy-inducing peptide. Nature 494(7436) 201 PMID: 23364696
Maejima (2016) Regulation of autophagy by Beclin 1 in the heart. J Mol Cell Cardiol 95 19 PMID: 26546165
Wong (2019) Intestinal epithelial tight junction barrier regulation by autophagy-related protein ATG6/beclin 1. Am J Physiol Cell Physiol. 316(5) C753 PMID: 30892937
Related areas
All cell penetrating peptides >
All protein-protein modulators >
All antivirals >
All regulated cell death categories >
Technical Data
| Structure | H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr-OH |
| CAS Number | 1423821-88-8 |
| Molecular Weight | 3741.15 |
| Formula | C164H251N57O45 |
| Sequence | YGRKKRRQRRRGGTNVFNATFEIWHDGEFGT |
| Modifications | None |
Solubility and Storage
| Solubility | Soluble in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
Batch Specific Data
| Purity | >95% by hplc |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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