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Sarilesin
Cat. No. AT-020
Structure:
Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH
Other Names:
[Sar1,Ile8]-angiotensin II
Activity:
Angiotensin receptor antagonist
Sarilesin, also known as [Sar1,Ile8]-angiotensin II, is a specific antagonist at angiotensin receptors. Sarilesin has multiple effects on vascular smooth muscle, including contraction of normal arteries and hypertrophy or hyperplasia of cultured cells or diseased vessels. Sarilesin activates both the NADPH and NADH oxidases, and stimulates superoxide anion formation in vascular smooth muscle cells.
Obermüller et al (1991) Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neurosci. Lett. 132(1) 11 PMID: 1787912
Matsoukas et al (1993) Synthesis and biological activities of angiotensin II, Sarilesin, and Sarmesin analogues containing Aze or Pip at position 7. J. Med. Chem. 1993 36(7) 904 PMID: 8464045
Related areas
All peptides >
All angiotensin receptor modulators >
All endocrinology research categories >
All cardiovascular research categories >
Technical Data
| Structure | Sar-Arg-Val-Tyr-Ile-His-Pro-Ile-OH |
| CAS Number | 37827-06-8 |
| Molecular Weight | 968.17 |
| Formula | C46H73N13O10 |
| Sequence | XRVYIHPI |
| Modifications | X is sarcosine |
Solubility and Storage
| Solubility | Soluble in water to 50 mg/ml |
| Appearance | Freeze dried solid |
| Storage | Store dessicated, frozen and in the dark |
Batch Specific Data
| Purity | >95% by HPLC |
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Recent citations
A new publication from the University of Ljubljana uses MCA-AVLQSGFR-Lys(Dnp)-Lys-NH2, the FRET substrate for the severe acute respiratory syndrome coronavirus main protease (SARS-CoV Mpro), to determine the inhibitory potential of plant polyphenols
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